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Re:Node.js is now available on App Engine standard environment by jkarneges on Tuesday June 12, 2018 @07:09PM (#17298907)
For handling incoming long-lived connections, you could pair with Fanout [1] (disclosure: founder). Basically the client sees a raw WebSocket, and your backend gets woken up with HTTP requests when things happen.

I haven't seen anything like this for outbound connections though.

[1] https://fanout.io

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