https://en.wikipedia.org/wiki/Johann_Hari#2011_scandals
His book Lost Connections has been strongly criticised for misrepresenting the mainstream scientific position, cherry-picking data and making unreferenced and unsupported claims.
https://anotherangrywoman.com/2018/01/22/thinking-critically...
That said, I found his book "Chasing the Scream: the first and last days of the war on drugs" [1] an informative resource that in some places touches on this thread's topic.
We observe a similar phenomenon with diseases like type 2 diabetes. People of south Asian origin have significantly higher risk of developing type 2 diabetes, even after controlling for diet and lifestyle factors. We have identified a cluster of genes that don't directly cause diabetes, but seem to increase the risk of developing the disease. You aren't doomed to develop diabetes if you have these genes, but you do need to be more careful about your diet and lifestyle.
(edited for clarity) Some say that depression is a chemical imbalance, but this is not a mainstream view any longer (I think, although it's often mentioned in comments on the Internet), although treatment is still very much based on chemicals like SSRI drugs, which have very little proven effect, require constant upping of dosages to gain the small effect they provide, and also having several undesirable side-effects.
I really recommend the book. If you're not convinced or just want an audio version, then I recommend the episode of the Ezra Klein Show podcast where Johann Hari is a guest - that's what convinced me to read the book.