UUID (or GUID on SqlServer) are essentially 128-bit integers. The fact they don't have inherent meaning beyond uniquely identifying a row and establishing referential integrity is a plus. In my opinion the primary key is for the database's needs; a human-friendly number or code for lookup is both optional and trivial to implement so when there's a requirement for an easy reference number or code for a record I use both a GUID for the primary key and a unique (or autonumber) field for human reference.