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Re:Show HN: Grayscale the Web – A Chrome extension to help a... by devastora on Tuesday May 22, 2018 @11:50AM (#17126838)
Thanks! I took a quick look and it doesn't seem like there's any plugins out there for grayscaling in Safari right now.

If you're talking about mobile safari though, you can do it on an OS level and toggle it by pressing the home button three times in a row - https://www.ped30.com/2018/01/13/apple-iphone-gray/

Re:Show HN: Grayscale the Web – A Chrome extension to help a... by beat on Tuesday May 22, 2018 @12:44PM (#17127281)
I just set my iPhone up for that. I am hoping it makes a positive difference.