I see the difference between creativity and insanity as a function of society. If a given society sees the connections as useful, it's creative. If instead, society cannot make sense of the connections, it's insanity.

As an analogy, mentally challenged children were seen as cursed in ancient Sparta and were routinely put to death. On the other hand, Mayan culture viewed mentally challenged children as "divine gifts," and the children could easily rise to positions of religious prominence and status in adulthood.

It's less a matter of the individual than how that individual can fit into society.