We have asyncio now to handle things in a non-blocking way with async/await. Someone just needs to write an implementation of asyncio.AbstractEventLoop that hooks into the Qt event loop.
Re:Hello Qt for Python
by always_good on Sunday May 06, 2018 @08:10AM
(#17006107)
And then they need to write an async version of everything you might want to use. And then they're done!
Qt (Qt Desktop) bindings for python are welcome. But, it's not a suitable for a viable replacement for electron. Maybe Qt Quick, but even qt quick has some decisions that can make incredibly uncomfortable to use in large applications.