Almost, when switching from PyQt4 to PySide 1. It was roughly equivalent with some minor differences. It was much less work than switching Python 2.7 syntax to 3. There are some bindings as well [1].

I don't know much detail about PyQt5 vs PySide 2 but at least the overall logic should be the same.

[1]: https://github.com/epage/PythonUtils/blob/master/util/qt_com...