They don't run under wine? (or in a Reactos vm? I assume they don't make sense to run in a vm, as if they did, you'd already run Windows in a vm?)
Clip Studio is close - really close, but color selection doesn't work and touch controls are messed up (especially with the stylus eraser). Touch support in Linux in general is awful, even with apps that I expect better of like Firefox or MyPaint, but it's almost good enough that I could tolerate it and switch anyway.
I'm semi-hopeful that it'll cross that line in a year or two, and especially hopeful that the work Purism is doing on the Librem Phone might speed that process up.
I honestly haven't tried to run a VM, I just assumed it would eat up battery too much to be useful - and since I use the tablet specifically for these apps, I'd have to spend all of my time in the VM anyway, which doesn't seem like much of an improvement :)
I hate that the updates are so pushy; I boot into the computer maybe two or three times a month and pretty much every time it wants me to restart and update something. I hate that it installs new updates on startup, I don't know who decided that when I turned on a computer I'd want to wait 3-4 extra minutes for stuff to install. I've been bitten by that multiple times during work presentations and calls.
I hate how glitchy the core OS touch support is; the touch keyboard only pops up about half the time, and manually getting it to show up is a pain. Unbelievably, Gnome is more consistent - which is saying something because Linux touch support is so bad. Periodically, the dock will just decide it doesn't want to hide anymore. There's about a 50% chance if I switch it into tablet mode that screen rotation will work. The default permission prompts don't always tell me which application is requesting authentication. I have #?x! ads in my start menu.
The whole UX is just really... buggy and nonsensical and it feels like none of the designers ever tried to use it outside of demo conditions. Maybe that's my device or whatever, but I'm on a Surface Pro. Microsoft should be able to get that right.
I could go on, but there's not much point. In comparison, my Linux desktop basically never breaks. I set it up once, and it just works. Same for my parents. Especially with the rise of the web, app support is good enough for them and, again, they want their apps to be usable, not flashy, and Open Source usually fits that criteria just fine. The type of person who can get by with an Android tablet instead of a desktop, could also probably get by with a small Linux laptop and might even prefer it now.
There are obviously exceptions, but I don't have a lot of problem recommending Linux to people anymore, because I've found most people want a computer that is set up specifically for them, and then they just want it to work consistently. (Opinion me) most people do not want their computers to evolve, or delight them or something.
I think the demographic that Windows and Apple court is real, but narrower than you might suspect.