yes, I actually subscribe to this view too. We are observing things at the borders of the capacity of our instruments that is so far removed from our natural habitat as humans that we may never understand much more. I don't think we should give up however, and the distinction between appearances and reality is fundamental to proceeding further IMO.

To clarify, it seems to me probable that real space itself (and time for that matter) is/are exempt from such localized notions. They probably 'permeate' or 'contain' everything, have always done and will always do, regardless of location and scale. It is obviously possible that they may lose relevance at a certain scale, but that scale is nowhere near our current horizon AFAICT.