I started skipping breakfast a while back after having a big dinner the night before and realizing I wasn't hungry. I felt better than if I ate just because it was "time to eat." Over time, I moved the threshold, and I don't eat breakfast, except for a shot of espresso. It feels much better.

Earlier, I had worked to cut out carbs at lunch (because they were making me sleepy in the middle of the afternoon). With breakfast being so simple, I have to make sure I have a healthy lunch (went out to eat and failed today), and then I don't stress too much about dinner. YMMV, but this system has worked really well for me.

As for the science, there's a lot of research, but no one really knows how all of our elaborate cellular machinery works. However, there seems to be some notion of the body being in "digestion" or "maintenance/repair" mode. Letting your body get into the latter mode seems to have some really good effects.