I use ES6 classes every day, and I would recommend it. However, for someone coming from a language like Python, it's easy to get confused over inheritance issues where JS does not behave like Python (or Java for that matter).

It doesn't need to be extreme. I just recommended writing one or two "classes" using the old style, in the beginning, because that's a great way to solidify understanding of how the inheritance actually works. Whereas when you're using ES6 classes, you're using hidden abstractions that can make debugging very confusing if you don't know what the "class" keyword is doing.