>> The bigger problem is “depression” is not reproducibly measurable, because it has no falsifiable or biomedical marker.

That's something I like to point out using SSRIs as an example. The claim is that they increase levels of serotonin and that the cause of the depression is reduced serotonin. The thing is, nobody actually checks your serotonin levels and says "oh that's low take this." Then there's the problem of why ones serotonin is low when it wasn't always that way. There are probably many causes of depression and quite possibly some that don't lower serotonin.

If mdma makes you friendlier, does that mean that people who are shy are suffering from friendliness deficit disorder and can I get a prescription for it.

>no more effective than exercise

You say this as if it were a bad thing but if SSRIs are as effective as exercise wouldn't that mean that they are very effective?

If you were to tell me a fat burning pill were no more effective than exercise I would start taking it.