Alcohol (ethanol) gets processed by the liver and enters the denovo lipogenesis pathway, becoming fat, which can accumulate in the liver if the lipid transporting machinery (LDL particles) are overwhelmed. This leads to Alcoholic Fatty Liver Disease (AFLD) and the "beer belly". Excess fructose consumption has been tied to Nonalcoholic Fatty Liver Disease (NAFLD) for many of the same reasons.
Some day we'll figure out why lipid droplet accumulation leads to insulin resistance. Some people think its tied to fuel selection and the evolved starvation response.
I suppose you mean the wine beer and spirits that people regularly consume with a meal, or some such.
But also, there are plenty of people who regularly drink one or more premixed alcoholic beverages.
Edit: stupid autocorrect
https://youtu.be/YpllomiDMX0