I use both Adobe and Autodesk, and neither yet support eGPU well. Essentially, if they wrote their own graphics engines (both adobe and autodesk did) then eGPU doesn't work that well. Lightroom has started to come over, and some features of Fusion360 seem to work OK, too, but for the most part the only eGPU accelerated parts of the apps seem to be the user interfaces.

Given Apple's recent obsession with AR/VR, I wouldn't be surprised if the new apple architecture was really GPU first, CPU second. Apple has always loved graphics, and in all likelihood they recognize that a more parallel OS model might actually suit people's day to day needs better.