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Re:MacOS finally gains external GPU support by jakemauer on Friday March 30, 2018 @02:39PM (#16718692)
This is unfortunately a known issue, at least in the community if not by nVidia. The current workaround is to patch an earlier known-good driver version to work on whatever release of High Sierra you're on. I'm currently running 387.10.10.10.25.106 on 10.13.3 without lag.

https://github.com/Benjamin-Dobell/nvidia-update

Re:MacOS finally gains external GPU support by mirthflat83 on Friday March 30, 2018 @02:58PM (#16718829)
Interesting that some people have no lags. I have also used that script, but stutters are still present.