Thalidomide, asbestos, DDT, commercial fishing, logging, industrial agriculture’s dependence on phosphate, western nations entirely addicted to oil … there are plenty of examples.

The overall positive trend is slowing down, with life expectancy in the USA dropping, mostly due to the opioid epidemic.

Overall the picture is pretty grim. Long term stability of civilisation is under threat due to fertility rates not falling fast enough to offset longevity. Food production is consuming limited non-renewable resources.