Yes, absolutely. The world has standardized on Unreal for big games and Unity for small to medium sized games. These come with enormous ecosystems and ready-made asset pipelines, which will dramatically decrease your time to market. Unless you're sitting on a fat pile of cash and free time that you can afford to never see again after you commit it to developing some experimental new engine and tools for the same, the smart thing to do is license Unreal or Unity.

That is, of course, assuming that you think sales are THE thing that matters in indie game development. In which case you are probably better off attaching yourself to a large studio such as EA, than going indie.