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A comment on You need 16 times the sample size to estimate an interaction than a main effect. Parent comment

Re:You need 16 times the sample size to estimate an interact... by evandijk70 on Saturday March 17, 2018 @03:55AM (#16605996)
It's part of it, but the described effect is amplified by the fact that if there are n variables, there are (n^2-n)/2 potential interactions. This increases the risk of finding spurious correlations due to multiple testing.
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