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Re:You need 16 times the sample size to estimate an interact... by thelamest on Saturday March 17, 2018 @01:02AM (#16605668)
If you're really interested, here are some other recent takes by statisticians on this issue: http://datacolada.org/17 https://approachingblog.wordpress.com/2018/01/24/powering-yo...

It's simply field experience that interactions are more typically subtler modifiers of strong main effects – here's a relevant quote from the second source:

>Unfortunately, very few times in psychology do we add a factor and expect a complete reversal of the effect. (...) [It’s] more usual that we expect the new condition to alter the size, rather than direction, of the existing effect.

Or from the first:

>[Whatever] power [simple effect study] had, at least twice as many subjects are needed in [interaction study], per cell, to maintain it. We know this because we are testing the reduction of that same effect.

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