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A comment on You need 16 times the sample size to estimate an interaction than a main effect. Parent comment

Re:You need 16 times the sample size to estimate an interact... by RA_Fisher on Friday March 16, 2018 @05:51PM (#16604272)
Andrew calls it the blessing of dimensionality: http://andrewgelman.com/2004/10/27/the_blessing_of/

Multi-level modeling's concept of partial pooling is really a killer feature.

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Re:You need 16 times the sample size to estimate an interact... by xitrium on Friday March 16, 2018 @11:28PM (#16605466)
Bob Carpenter did a great case study on the this topic, for anyone new to it: http://mc-stan.org/users/documentation/case-studies/curse-di...

Check out the graphs, especially of the euclidean distance from the mode of a random point as dimensions increase.

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