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A comment on Vaccines against addictive drugs push forward despite past failures. Parent comment

Re:Vaccines against addictive drugs push forward despite pas... by danieltillett on Friday February 23, 2018 @04:53AM (#16445311)
I was under the impression that past heavy (ab)users of opioids no longer get any analgesic benefit from them?
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Re:Vaccines against addictive drugs push forward despite pas... by Blindedwino on Friday February 23, 2018 @05:24AM (#16445441)
Yes, I had a friend who was an ex heroin addict, she needed huge quantities of any sort of painkillers to get any effect.
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Re:Vaccines against addictive drugs push forward despite pas... by epmaybe on Friday February 23, 2018 @08:07AM (#16446060)
It goes back to basically any medication that acts on G Protein Coupled Receptors (of which opioid Receptors fall under). If given the same dose for over 10 days, by day 3 you are seeing a significant loss of analgesic effect.
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Re:Vaccines against addictive drugs push forward despite pas... by freedomben on Friday February 23, 2018 @04:34PM (#16449829)
It depends on how long in the past things were. Over time the body gets closer and closer to "normal."
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