It depends on the market, locally, the owner of a major theater chain has adopted digital projection on something like 35+ screens in the greater metro area and has really been open to some of the smaller indie films. Many times it takes a lot of vision on the part of the theatre owner/manager because indies can really depend on the "long tail" when it comes to theatre audiences. They don't have the money to advertise so you run the film for a week and hope those people tell their friends and they tell there friends and pretty soon you start to see some steady returns as the word gets out, but this takes some guts and patience from the owners.

Net distribution will be a great avenue as well, given how reticent the studios have been to band together and provide "one" place where people can go to rent/buy films online.