It's intuitive, until it isn't. I can from the top of my head cite various autobahn crossings in Germany where you need to keep on the left to ultimately go right because you're going through an underpass: The A81 crossing in Heilbronn coming from Heidelberg, the crossing at Dreieck Funkturm in Berlin coming from Potsdam, ...

It's also often useful to know how many lanes can be used for a turn, etc, so you can switch lanes early.