Your question relates more to IPython Kernel than Jupyter per se. Fortunately ipykernel has out of the box integration with event loops, e.g. https://github.com/ipython/ipykernel/blob/master/ipykernel/e... for asyncio integration, and you can then schedule cell updates on the asyncio event loop as you would normally. To have events on the Python side generate visible updates in the Jupyter notebook you can use ipywidgets, for which the Python widget state in the kernel is automatically synchronized to the JavaScript widget state.