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Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by phkahler on Sunday February 18, 2018 @09:01AM (#16406106)
My first reaction to these things is that there should be a large database of diseases and symptoms along with some statistics about how strong the correlation is between the disease and symptoms. I don't mean "database" like pubmed. I mean something more machine readable with consistent coding so a symptom might be "elevated IgM" in english. The trick is coding something like that with consistent names for the tested item and consistent definitions of "elevated". Perhaps the definition of elevated would depend on the disease?

One should be able to then filter the disease database based on symptoms. Doctors seem to do this in their head, but they are not comprehensive stores of information. I suppose the problem is in the encoding of symptoms, it's not that simple.

Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by jdmichal on Sunday February 18, 2018 @10:13AM (#16406392)
The only appropriate definition of elevated is higher than normal for that patient. Unfortunately, doctors rarely have a baseline to work from, so they use statistics instead. A relative of mine had a PSA test that read statistically normal. Luckily he looked at the actual number and saw that, while it was within statistical normal, it was in fact higher than any other prior reading for him. Further testing came up positive for prostate cancer. If he hasn't been paying attention, that would have been another year of cancer until the next check.
Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by eismcc on Sunday February 18, 2018 @12:15PM (#16407003)
It’s hard to convince institutions to release data locked up in EHRs (eg EPIC) due to the labor involved (EPIC is not well structured for this), risk of accidentally leaking PHI, and general motivation (getting hold of useful data is the bread and butter for career researchers).
Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by bluesign on Sunday February 18, 2018 @11:38AM (#16406798)
The main problem here is human body works in mysterious ways.

We are by definition reacting different, and unfortunately statistics are not helping on this case.

Basically, we have:

- too many illnesses (I guess 10% of top common health problems, covering 90% of all problems)

- for each illness, we have N number of symptoms (which unfortunately all or only a subset of this can occur)

- then we have fake symptoms (statistically out of threshold values but we are living fine with them)

this is generating a big number of combinations.

With this much combinations, it is requiring extensive amount of tests.

As everything health is also optimized for the greater good. Which requires optimum cost management.

So basically medicine today, with statistical approach, is happy to skip 1%, if it can fix 99% with 90% less cost.

Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by T2_t2 on Sunday February 18, 2018 @07:44PM (#16409912)
> - too many illnesses (I guess 10% of top common health problems, covering 90% of all problems)

I think this is probably the easy thing to fix when it comes to searching, as you could pretty much leave out the common diagnoses as they'd likely have been tried - Imma call this the "Dr House, is it Lupus?" filter.

From there, you could have "try this" filter, and see what the results are. I wonder what the overlap is between tests and symptoms, but surely with 10 tests and 10 symptoms, most illnesses could be mostly identified?

Re:Her Various Symptoms Seemed Unrelated, Then One Doctor Pu... by pjc50 on Sunday February 18, 2018 @09:20AM (#16406178)
This was one of the early areas of AI research, which seems to have gone nowhere: https://en.wikipedia.org/wiki/Mycin