In my experience, yes. I tried an Dell XPS 15 for a few weeks and the 4K pain points were evident with apps like Audacity, Photoshop, and VLC. I ended up learning more about Apple's high-DPI approach:

https://forums.macrumors.com/threads/is-mac-retina-scaling-f...

Laptops aside I've read that using a large enough display, at least 32", helps work around the Windows scaling issues. I haven't tried this yet.