Not answering the real question but we have a lot of little wxPython GUIs driving big engineering design software suites at the advanced nuclear design company I work at. Engineers (mechanical, nuclear, etc.) can grasp it fairly quickly, get their knobs on the screen, and be back to doing their mechanical and nuclear engineering. We got started because the original python guy (me) learned it from a grad student in 2005 via the excellent wx docs and demos collection of examples. Works great and we recently went all Python 3.