Looking at the readme, I noticed our examples our not as featured as I thought so sorry for the harshness. But following the link to the examples, leads to a example called "Tutorial - Transfer files between the browser and other IPFS nodes" which explains how you can connect a js-ipfs node with other nodes, like go-ipfs that runs on desktop. Link: https://github.com/ipfs/js-ipfs/tree/master/examples/exchang...

go-ipfs, which I guess you refer to with the mainstream network, has support for websockets which the browser nodes has support for as well, so they can interop.