I lived in Southtown. Right at South Alamo and Flores. I needed a car to be able to grocery shop and get to work. A 10-15 minute drive to the office was anywhere between a one-hour and two-hour bus ride.

In practical terms, it would have been workable if my office had been along the Riverwalk. Otherwise, not really. SA's public transit isn't usable for white-collar professionals in most cases.