It's been a while since I haven't use wine. Actually, it's been since Steam started its push for linux support in games.

But it still happens that I will use wine for games I really want to play and which do not have linux support (it's extremely rare I want a game that bad, the last one was No Man's Sky). Being able to launch them just like a native app when I feel like playing is a huge advantage (not even sure it would work properly in a virtual machine, with its dedicated RAM and CPU limits).

So I guess my usecase for wine is "gaming fallback". Not that I speak for the majority, obviously, let see what other people have to say about it. :)