You could use it inside your custom game engine, but it wouldn't make much sense. Most 2D games work with bitmaps and sprite-sheets and Skia gives you full vector graphics. It's huge dependency, inflates your executable by few tens of megabytes and still doesn't give you window management and input handling and so on. SDL is still the king here - it provides just enough to build upon in reliable and cross-platform fashion.

Skia would be more useful for graphical applications focused on vector graphics (diagrams, plots, layout editors, CAD...). And for general purpose 2D graphic platforms like browsers have.