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Re:Albert Hofmann discovers the effects of LSD (1943) by cairo_x on Monday January 08, 2018 @04:04AM (#16095560)
You can't get high from LSD by touching it. Albert is a liar. He nibbled some.

My theory is, he knew those in the know know that this is an impossible way to get high, which is why he stuck with it (a crafty wink). He could have simply said he got a little on his finger and touched his mouth, but he stuck with the skin absorption story.

Just a little harmless tinfoil.

Re:Albert Hofmann discovers the effects of LSD (1943) by matt4077 on Monday January 08, 2018 @04:38AM (#16095662)
It's one of those 'lies' that benefit humanity, considering the alternative would have been not to share the knowledge with the world. Because he was obviously fearing difficulties with his employer if he admitted to such a breach of standard protocols.

It reminds me of one of the early anatomists–Leonardo da Vinci, maybe? They found the cause of one of the leading causes of death at the time: appendicitis. In their publication, they invented a story about an ailing soldier being killed in such a way that the inflamed appendix was exposed. It was a lie, and a rather obvious one. But it was necessary because dissection was forbidden at the time.

Re:Albert Hofmann discovers the effects of LSD (1943) by asteli on Monday January 08, 2018 @04:26AM (#16095632)
The tone of your post encouraged me to challenge your assertion, but it does actually appear from numerous anecdotes that LSD is very poorly absorbed transdermally, even when dissolved in solvents used for that purpose.

Neat.

Re:Albert Hofmann discovers the effects of LSD (1943) by peg_leg on Monday January 08, 2018 @07:41AM (#16096318)
Perhaps with microgram amounts - common dosages. He was working with a huge amount ... milligrams. The idea that a microgram may transmit transdermally is not inconceivable at that amount.
Re:Albert Hofmann discovers the effects of LSD (1943) by bonesss on Tuesday January 09, 2018 @08:50AM (#16106088)
I'd also challenge the idea of an active scientist "getting things in his mouth" or ingesting new chemical compounds for the heck of it (at doses almost legendarily small compared to most drugs etc)...

Knowing that the compound is not dangerous or toxic handling some with the hands, or improper inhalation, sounds reasonable. Being in the habit of nibbling on your synthesized chemicals sounds kinda wonky.

Not to mention, there is no real motivation to lie here, unless Hofmann were a routine imbiber of random chemicals and wanted to keep his dark secret. LSD was legal at the time.

Re:Albert Hofmann discovers the effects of LSD (1943) by DanBC on Tuesday January 09, 2018 @08:58AM (#16106140)
> I'd also challenge the idea of an active scientist "getting things in his mouth" or ingesting new chemical compounds for the heck of it (at doses almost legendarily small compared to most drugs etc)...

We're talking about the 1940s, when things were a bit different.

See the history for saccharin, cyclamate, and aspartame for other examples of accidental ingestion.

Re:Albert Hofmann discovers the effects of LSD (1943) by bonesss on Tuesday January 09, 2018 @11:28AM (#16107310)
Have any chemicals been ingested accidentally since 1940? Sure!

Are trained chemists with PhDs in the subject working with complex synthesis and dangerous chemicals in the habit, from 1929 to present day, of putting those things in their mouths? Awwww heck no.

And 1940 is near the point we cracked the atom... we knew oodles about dangerous chemical and safe handling practices. Accidents will happen, but the (speculative) fiction we are discussing here is Albert Hoffman intentionally eating LSD and lying about it :)

----

Saccharin, the oldest artificial sweetener, was accidentally discovered in 1879 by researcher Constantine Fahlberg -- Fahlberg was working with coal, and had no PhD AFAICT.

Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of anti-fever medication. He put his cigarette down on the lab bench, and, when he put it back in his mouth, he discovered the sweet taste of cyclamate -- a student, smoking in his messy lab

Aspartame was discovered in 1965 by James M. Schlatter, a chemist working for G.D. Searle & Company. Schlatter had synthesized aspartame as an intermediate step in generating a tetrapeptide of the hormone gastrin, for use in assessing an anti-ulcer drug candidate.[65] He discovered its sweet taste when he licked his finger, which had become contaminated with aspartame, to lift up a piece of paper -- an actual chemist, but working with something with a well known composition and known to be relatively harmless

Re:Albert Hofmann discovers the effects of LSD (1943) by saiya-jin on Monday January 08, 2018 @08:04AM (#16096409)
full single dose is +-100 micrograms. you won't feel anything at all from a single ug. trans-dermal 'theory' really doesn't hold well
Re:Albert Hofmann discovers the effects of LSD (1943) by Nabi on Monday January 08, 2018 @06:22AM (#16096035)
FIY
Re:Albert Hofmann discovers the effects of LSD (1943) by cairo_x on Monday January 08, 2018 @06:31AM (#16096070)
FIY "sticking one's thumb into pure LSD powder and licking it off"
Re:Albert Hofmann discovers the effects of LSD (1943) by 3131s on Monday January 08, 2018 @05:16AM (#16095795)
From everything I know, that's not true of crystal LSD. Ever heard of thumbprinting?
Re:Albert Hofmann discovers the effects of LSD (1943) by deno on Monday January 08, 2018 @05:30AM (#16095844)
> A thumbprint is a method of consuming a massive amount of lsd, where a massive (relatively, compared to a blotter dose) amount of lsd crystals are made into a small pile, pressed on with a thumb, and then the thumb into the mouth.

The ROA is still oral.

Re:Albert Hofmann discovers the effects of LSD (1943) by cairo_x on Monday January 08, 2018 @05:39AM (#16095869)
Unless it was (literal) 'needlepoint' LSD... maybe he stabbed himself with a shard? /s
Re:Albert Hofmann discovers the effects of LSD (1943) by deno on Monday January 08, 2018 @07:55AM (#16096367)
Well that would at least work.
Re:Albert Hofmann discovers the effects of LSD (1943) by 3131s on Monday January 08, 2018 @06:25AM (#16096045)
Sure, but the accounts of thumbprinting I've read made it seem like there is a strong sensation almost immediately after touching it. I also know people who have described a contact high from laying sheets of LSD. Hmm... I could be wrong though.
Re:Albert Hofmann discovers the effects of LSD (1943) by moron4hire on Monday January 08, 2018 @07:59AM (#16096388)
That's not what "contact high" means. Contact high is a high feeling reported by people who have been in contact—as in in proximity, not physical contact—with other high people.
Re:Albert Hofmann discovers the effects of LSD (1943) by saiya-jin on Monday January 08, 2018 @08:08AM (#16096427)
That is most probably not true at all. Any stuff put on rather thick skin of our fingers (especially solid crystals, unlike some liquid) would take considerable amount of time to get into bloodstream and finally brain. Look at how long does it take for a space cake to kick in, and it goes to places specifically designed to dissolve & absorb material.

Don't believe all written on internet (says internet comment :))