I think that the application of information theory to large systems of chemical reactions is likely to be fruitful. As your source says, it will be important for biological systems, with their myriad interlocking reactions. From my perspective, an issue is that this calculation takes as input the rate constants of the reactions, whereas my research has been at the level below this: finding the rate constants (and similar properties). This can be quite difficult, so my mind boggles a bit at the idea of a calculation which requires large amounts of such data.