I've written a few minor Tk based apps in Python and if you look at Rebol (Red's ancestor) it is much much much easier to build a similar GUI. This Rebol guy has several sites where he builds dozens of small applications that are almost freaking one liners:

http://guitarz.org/howtomakeaprogram.com/howtomakeaprogram.h...

http://easiestprogramminglanguage.com/easiest_programming_la...

http://business-programming.com/business_programming.html

http://personal-programming.com/personal-programming.html