Sure. A mass extinction event which will take humans with it. Then a few million years down the line new speciation will fill all of the ecological niches in whatever equilibrium arises. The planet and life themselves are unlikely to be completely wiped out, absent some future technology we can’t yet imagine.

As long as you don’t have any attachment to anything more narrow than “all life on earth” (e.g. your family, language, city, country, culture, species, ...) thriving for a long time into the future, there’s no reason not to just shrug at whatever impending apocalypse.