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Re:Haemophilia A trial results 'mind-blowing' by DoreenMichele on Thursday December 14, 2017 @05:17PM (#15927706)
I don't think that is far-fetched. The gut contains about 70% of the cells of your immune system.

I have a genetic disorder. Working on my gut health has gone a long way towards reversing my symptoms.

I don't talk about it as much as I used to because it was a constant shit show from people being completely dismissive, outright calling me crazy and asserting utterly illogical things in the name of their "scientific" bias, like "Your 13+ years of steady forward health progress in the face of your degenerative condition is merely wild coincidence and doesn't prove that you know anything at all. Stranger things have happened!"

Cuz, yeah.

People who see themselves as scientific and logical are very often not remotely objective. They just have college degrees or whatever to justify their ugly personal prejudices, and don't confuse them with the facts.

Re:Haemophilia A trial results 'mind-blowing' by carbocation on Thursday December 14, 2017 @06:33PM (#15928369)
I don't think there is a relationship between your personal experience and the OP's claim that diseases, broadly, are typically mediated by the gut microbiome.
Re:Haemophilia A trial results 'mind-blowing' by DoreenMichele on Thursday December 14, 2017 @06:36PM (#15928399)
So explain to me how 70% of the body's immune cells being in the gut is unrelated to how diseases are typically mediated. Pretty please.
Re:Haemophilia A trial results 'mind-blowing' by wahern on Thursday December 14, 2017 @08:37PM (#15929063)
The gut contains 70% of immune cells because your gut is actually the main point of contact between your body and the external environment. The surface area of your gut is somewhere from 20x to 100x that of your skin.

One could just as well argue that because the immune system is so well developed and robust in the gut that it's the last place to look for dysfunction. Or one could argue that a 70% share of immune cells is rather low considering the relative ratio of environmentally-exposed surface area.

We could say all kinds of things if we're free to make unsubstantiated conjectures. But we really can't say anything of substance without context and evidence. The human organism is ridiculously complex and consistently defies intuition.

Re:Haemophilia A trial results 'mind-blowing' by DoreenMichele on Friday December 15, 2017 @05:12AM (#15930810)
Thank you for taking my question seriously.

I don't agree, but I appreciate the expanded perspective.