Check out https://www.rigetti.com/ if you want to work with python.

Hopefully once the technology matures and becomes more widespread we get a FOSS alternative. I don't trust Microsoft and would not want to work with a stack that is monopolized by them

I think this is crucial.

Rigetti Computing (where I work) has open-sourced several packages related to quantum programming, including pyQuil: https://github.com/rigetticomputing/pyquil