Impressive. An important point here seems to be that these ASO's have a chemically modified backbone which prevents degradation by exonucleases. But the bases are un-modified allowing complimentary pairing and activation of RNAse H activity. Even so, I'm surprised they're able to cross the cell membrane in high enough quantities to have therapeutic effects. Apparently, these techniques have been around since the mid-nineties or so. TIL...