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Re:Dinosaur tail discovered trapped in amber (2016) by throwaway613834 on Saturday December 09, 2017 @05:53PM (#15888664)
In what sense does DNA have a half-life? It can't be radioactivity so is it seems to be just about molecular disintegration? Which is weird because why should a stable structure have a half-life?
Re:Dinosaur tail discovered trapped in amber (2016) by anamexis on Saturday December 09, 2017 @05:58PM (#15888685)
The introduction of the first citation explains it a little bit:

> DNA has limited chemical stability and decays without the enzymatic repair mechanisms of living cells [18]. Following cell death, nucleases start to cleave the DNA into fragments [19] and during decomposition, the DNA is digested by micro-organisms [18,20]. In determining long-term DNA decay, it is believed that hydrolysis of amino groups accelerates the loss of purine residues (depurination), resulting in strand cleavage [21,22]. This random DNA fragmentation generates a characteristic negative exponential correlation between DNA fragment length and number of molecules (figure 1a) [23,24,26,27].

Re:Dinosaur tail discovered trapped in amber (2016) by garmaine on Saturday December 09, 2017 @09:46PM (#15889553)
To be fair, many of those processes are things that I would presume halt at some point in an isolated chemical environment.

Also, what kind of breakdown? If segments up to a certain sizer were stable, that would be enough to reconstruct a full genome of the sequencers were sensitive enough and the final segments long enough.

Re:Dinosaur tail discovered trapped in amber (2016) by throwaway613834 on Saturday December 09, 2017 @06:02PM (#15888700)
Thanks! I even clicked on the link and read every sentence that had "half" in it but didn't see anything... didn't expect it to be somewhere else in the introduction haha.
Re:Dinosaur tail discovered trapped in amber (2016) by delecti on Saturday December 09, 2017 @08:41PM (#15889295)
As a general rule, it's safe to assume every word in the abstract of a paper is significant.
Re:Dinosaur tail discovered trapped in amber (2016) by throwaway613834 on Saturday December 09, 2017 @08:54PM (#15889357)
> As a general rule, it's safe to assume every word in the abstract of a paper is significant.

...what? The sentence quote above was from the introduction, not the abstract. Nothing in the abstract answered my question of why a stable structure like that of DNA should undergo disintegration. (Did you read the abstract yourself?)

Re:Dinosaur tail discovered trapped in amber (2016) by jacquesm on Saturday December 09, 2017 @06:28PM (#15888793)
DNA has a half life, but the real question here is how being trapped in amber would affect that half life. So there may be more - or less - than one would expect if the DNA would be in some other environment. At a guess the time span involved is long enough that no matter how this would be influenced there still would not be any usable DNA fragments.
Re:Dinosaur tail discovered trapped in amber (2016) by yread on Sunday December 10, 2017 @04:11AM (#15890619)
Another question is what sort of artifacts would sequencing material in amber produce. Considering the quality of data from formaldehyde fixed paraffin embedded (FFPE) samples I think it would be quite a struggle
Re:Dinosaur tail discovered trapped in amber (2016) by barrkel on Saturday December 09, 2017 @07:58PM (#15889113)
All exponential decay processes have half-lifes - or rather, half-life is a metric that describes the scale of an exponential decay rate.

https://en.wikipedia.org/wiki/Exponential_decay

Re:Dinosaur tail discovered trapped in amber (2016) by skadamou on Saturday December 09, 2017 @06:13PM (#15888738)
This link might help answer your questions. Also, half-life in this context is just referring to how long it takes the number phosphodiesterase linkages (bonds holding the DNA backbone together) to decrease by 1/2. Half-life can refer to other types of decay as well :-)

https://www.nature.com/news/dna-has-a-521-year-half-life-1.1...

Re:Dinosaur tail discovered trapped in amber (2016) by crooked-v on Saturday December 09, 2017 @06:41PM (#15888831)
Everything has a half-life. Even plain old protons have a theoretical half-life of of 10^31 to 10^36 years.

https://en.wikipedia.org/wiki/Proton_decay

Re:Dinosaur tail discovered trapped in amber (2016) by whatshisface on Saturday December 09, 2017 @10:52PM (#15889773)
Proton decay is not a feature of the standard model, it comes from other theories with far less experimental evidence behind them; by no means at this point can we say that protons "have" a half-life.