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Re:Amazon is in exploratory talks with generic-drug makers by refurb on Friday December 01, 2017 @05:30PM (#15828297)
I work on the drug manufacturer side so we deal with pharmacy reimbursement issues as well.

Large pharmacies like Walgreens negotiates contracts directly with insurers. Smaller independent pharmacies band together to negotiate as a group.

Because so much discounting and rebates happen on drugs, it's actually really hard for an insurance company to know what a pharmacy paid for a drug. Plus, there are so many drugs, it's hard to negotiate each one. What you end up with are blended reimbursement rates. An insurer might agree to pay 5% below list for all blood pressure medication. The pharmacies then try and get the best price they can. As a result, they make a lot of a handful of drugs, a slim margin on most and lose money on a few.

PBMs that own pharmacies (Express Scripts is the biggest) are in a unique situation where they know both side of the transactions - what the purchase price was so they can set reimbursement.

There are also DIR fees happening where PBMs clawback additional funds later on. That makes knowing the actual margin for a pharmacy really hard to determine until the transaction is already complete.

Re:Amazon is in exploratory talks with generic-drug makers by conductr on Friday December 01, 2017 @05:49PM (#15828441)
Agree. It’s complicated as all hell. PBM is where I think amazon should start for reason you stated

I’ve worked in a couple of healthcare segments over a couple decades. One thing I’ve come to learn is things can never be simple. I think economic complexity somehow adds s ton of system cost. If nothing else it adds layers of middlemen