No, this is a huge myth. I’m getting older (42) and my eye sight is getting worse, and I can still tell the difference between 110 and 220. Heck, I could easily tell the difference between 150 PPI and 220 (a hitachi 28” 4K vs. a iMac retina 5K).

Coding without seeing pixels in font rendering is just bliss, it is too hard to go back.