This is unfortunately true, though it doesn’t have to be. The problem with webapps generated with JavaScript is that it’s tempting to create a custom implementation of built-in functionality. Good old anchor tags are “visible” to screen readers that visually impaired people use to browse the web. Chances are your JavaScript Link hack isn’t because you forgot to include the role=“link” attribute. Keybinding extensions are similarly blind when developers write inaccessible markup.
The solution is for developers to spend a day learning about accessibility. A good starting point is https://webaim.org/intro/.
They're mostly a way to use the regular browser functions, only with the keyboard rather than the mouse. But this works best for regular sites, and poorly for webapps that use JS-activated links and such.