Re:As epidemic rages, ER study finds opioids no better than ...
by astura on Thursday November 09, 2017 @11:15AM
(#15663577)
>In a randomized, double-blind clinical trial—the gold standard of trials—a combination of ibuprofen (Advil) and acetaminophen (Tylenol) was just as effective at treating patients with acute pain in an extremity as three other pain-killer combinations containing opioids.
They tested medicine combinations (400mg of ibuprofen and 1,000mg of acetaminophen), not ibuprofen alone.
Extremity pain (arms and legs) was tested only, not pain in general.
They only tested medications delivered orally, not intravenously. That distinction is very, very important as intravenously administered medications have a much higher placebo effect than orally administered medications. In fact, I'd love to see a comparison of orally administered opioids vs intravenously administered NSAIDs.
They tested medicine combinations (400mg of ibuprofen and 1,000mg of acetaminophen), not ibuprofen alone.
Extremity pain (arms and legs) was tested only, not pain in general.
They only tested medications delivered orally, not intravenously. That distinction is very, very important as intravenously administered medications have a much higher placebo effect than orally administered medications. In fact, I'd love to see a comparison of orally administered opioids vs intravenously administered NSAIDs.