For a couple of years, the only thing that worked for me was mega-huge doses of PPI's. After several pH studies, endoscopies, and other tests confirmed that I don't have abnormal reflux, food allergies, gluten sensitivity, or anything else, my doctor(s) and I found after years of trial-and-error that a combination of H2 blockers and a low-dose of antidepressants mostly controls my symptoms, which are probably caused by an overly-sensitive gastric nervous system.