Or, to ask another way, is there any reason to prefer anything other than Vanguard's Index500 vs anything else attempting to replicate the SP 500? (I call out the Vanguard fund because the fees are very low, .14% iirc.)
Mutual funds: recurring investment of any dollar amount (fractional shares). Minimum initial investment required. Trade once per day, beware loads, fees, and expense ratios
ETFs: buy or sell one or more whole shares, trade throughout the day, beware trading commissions and expense ratios.
Vanguard's prices are great, especially if you get into their top-tier $10,000+ accounts. But ETFs are competitive against Vanguard in my experience.
Of course, Vanguard also offers low-cost ETFs. As long as you go with a mainstream option, I don't think you can go wrong.