Jake from TileDB, Inc. In addition to the differences pointed out in the paper, I think SciDB and TileDB are very different philosophically. SciDB is architected very much like a traditional RDMS while TileDB is much more lightweight. SciDB encourages you to use their own query language (AQL), TileDB wants to integrate and extend the high level tools you already use (Python, R, etc.) with as little overhead as possible.