Just like communism, real science is infallible.

Seriously, is there a threshold? If this continues for, say, a hundred years, will science have failed then? A thousand?

What would it even mean for “science” to have failed? Science is just testing your assumptions against reality to gain knowledge.

If you mean the academic institution of, uh, Big Science or whatever you’d call it—sure, it has failed in its current incarnation to impose the rigour for reproducibility, and incentive toward reproduction. But academic institutional cultures evolve in response to noticing problems like that. Like software evolves in response to discovering vulnerabilities. A given institutional culture (like a given piece of software) won’t have the same vulnerability twice; if Big Science is still having crises 1000 years from now, they will be new and different crises.

The thing is, even fallible science is better than non-science. The only thing that has consistently put understanding of the universe forward is science. I mean, if we don't trust the scientific method, what's the alternative? Bible?