A lot of that, in the specific case of milk, is that farther out from cities you can sell it fast enough to make sense. Milk is, legally speaking, "good" for about 2 weeks from the time it comes out of the cow. If you're in a city where everyone eats out at all meals, you might not sell enough out of one store to avoid spoilage. This means that costs to the store go up since they either have to pass on high trucking fees per gallon for buying few gallons, or they amortize those costs and end up charging more per gallon because they throw a lot of it out. Conversely, out in farming country where I grew up, the closest restaurant was 20 minutes drive away, so we didn't eat out much and bought a lot more groceries than the people I lived with in NYC. This means that the Meijer in town rarely has to throw out milk for being passed the sell by date, and is large enough, with people coming in from a 50 mile radius, to move the volume to get volume discounts. Doesn't hurt that a reasonable quantity of their milk is bottled in town and comes from cows about a mile from my house... "Far from transportation hubs" is relative to what you're transporting...