The only problem is that everytime he/she wants to execute Hy (Python in s-expression syntax) code, he will invoke the macro "org-babel-execute:hy", and this runs Hy as a shell command.

So Common Lisp objects can't be quickly copied or shared to Python, and for each invocation there is a time overhead.

I'd love to see a good bridge from Common Lisp to Python. It should be possible.