This is true for occupations like sales where the litmus test is professionalism and the ability to stick to goals. However, you will lock yourself out of occupations with degree requirements for credentialing and those with domain knowledge you gain through school like Chemistry.

I live in LA and, surprise surprise, there are a lot of writers, artists, and other folks who want to work in Liberal Arts oriented industries. Most of my Liberal Arts degree equipped friends are in sales while dabbling in their art on the side. A few of them sell a book or script every 3-5 years. The rest of them went back to school for a Law Degree or an unrelated Masters degree.